反应详情

2-Amino-2-methyl-propionyl chloride hydrochloride (150 mg, 1.2 mmol) and 2-benzyl-5-phenyl-2H-pyrazol-3-ylamine (200 mg, 0.8 mmol) were stirred in DCM (5 mL) containing triethyl amine (100 μL, 0.8 mmol). After two hours, 2-chlorophenyl isocyanate (220 mg, 0.9 mmol) and triethyl amine (100 μL, 0.8 mmol) were added. Purification by silica gel chromatography gave the title compound. 1H NMR (400 MHz, DMSO-D6) δ 1.44 (s, 6H) 5.23 (s, 2H) 6.54 (s, 1H) 6.92 (s, 1H) 7.17 (s, 4H) 7.24 (s, 3H) 7.36 (s, 3H) 7.55 (s, 1H) 7.74 (s, 2H) 8.04 (s, 1H) 8.15 (s, 1H) 9.81 (s, 1H). m/z 488.0 (MH+).

1. customPurification by silica gel chromatography