N-(4-Bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinamide → 5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide

HRID 2368663노트

반응식

HRID 2368663 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:26])[C:10]2[CH:15]=[C:14]([N+:16]([O-])=O)[C:13]([NH:19][CH3:20])=[N:12][C:11]=2[O:21][CH2:22][CH:23]([F:25])[F:24])=[CH:4][CH:3]=1>[Ni].C1COCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:26])[C:10]2[CH:15]=[C:14]([NH2:16])[C:13]([NH:19][CH3:20])=[N:12][C:11]=2[O:21][CH2:22][CH:23]([F:24])[F:25])=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 86664893N-(4-Bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-5-nitro-nicotinamide

생성물 1

HCID 866648925-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

Prepared analogously to example 154d by hydrogenation of the product obtained in (771f) using Raney nickel in THF.

후처리

  1. customPrepared analogously to example 154d by hydrogenation of the product

출처 및 근거

ORD 기록
ord-543ae5d2267346549c3773248a77fe4b
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08703796B2

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