Hydrochloric Acid → Benzamide

HRID 236869노트

반응식

HRID 236869 반응식
Cl[C:2]1[CH:3]=[CH:4][C:5](OC)=[C:6]([CH:10]=1)[C:7](Cl)=[O:8].Cl.C(C1C=CC(CC[NH2:24])=CC=1)C.N1C=CC=CC=1.Cl>C1(C)C=CC=CC=1.O>[C:7]([NH2:24])(=[O:8])[C:6]1[CH:5]=[CH:4][CH:3]=[CH:2][CH:10]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 123841765-Chloro-2-methoxybenzoyl chlorideHCID 213155294-Ethylbenzeneethanamine hydrochloride

생성물 1

HCID 2331Benzamide

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매2회

실험 절차

A solution of 4.1 g of 5-chloro-2-methoxy-benzoyl chloride in 20 ml of toluene was added dropwise to a suspension of 4.65 g of 2-(4-ethylphenyl)-ethylamine hydrochloride in 100 ml of anhydrous toluene after addition of 5 ml of pyridine. The whole was heated under reflux, then shaken with water, dilute hydrochloric acid and a solution of sodium bicarbonate and dried over sodium sulfate. After concentration under reduced pressure, the residue, which solidified only slowly, was filtered off with suction after addition of petroleum ether (B.p. 30°-60° C.). The 5-chloro-2-methoxy-N-(2-<4-ethylphenyl>-ethyl)-benzamide so obtained was found to melt at 66°-68° C.

후처리

  1. temperatureThe whole was heated
  2. temperatureunder reflux
  3. dry with materiala solution of sodium bicarbonate and dried over sodium sulfate
  4. concentrationAfter concentration under reduced pressure
  5. filtrationwas filtered off with suction
  6. additionafter addition of petroleum ether (B.p. 30°-60° C.)

출처 및 근거

ORD 기록
ord-8873582cdcbd4096a46fbee0bab7ceb6
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04158063

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