Benzaldehyde → 4-(2-Phenylethenyl)pyridine

HRID 236881

반응식

HRID 236881 반응식
[NH+:1]1[CH:6]=[CH:5][C:4]([CH3:7])=[CH:3][CH:2]=1.[CH:8](=O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.N1CCCCC1.[OH-].[Na+]>C(O)(C)C>[CH:7]([C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1)=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

6

반응물 4

HCID 240BenzaldehydeHCID 8082PiperidineHCID 14798Sodium HydroxideHCID 34343784-Methylpyridinium

생성물 1

HCID 1015764-(2-Phenylethenyl)pyridine

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To 67.5 parts of the 4-picolinium quaternary salt as in Example 13 but without the acid salt was added 100 parts isopropanol, 32.5 parts benzaldehyde, and one part piperidine. The resulting solution was boiled at reflux two hours, 100 parts 40% sodium hydroxide added, and the heating continued for two hours. The cooled mixture was extracted with chloroform, and the organic phase evaporated to dryness to yield a residue that was recrystallized from methanol-water to give 21 parts 4-styrylpyridine.

후처리

  1. temperatureat reflux two hours
  2. extractionThe cooled mixture was extracted with chloroform
  3. customthe organic phase evaporated to dryness
  4. customto yield a residue that
  5. customwas recrystallized from methanol-water

출처 및 근거

ORD 기록
ord-34760d1e90e14ea3aa3e2fc44893f46d
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04158093

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