Phenylacetyl chloride → HCID 5324449, 화합물

HRID 236896노트

반응식

HRID 236896 반응식
[CH3:1][C:2]1[S:6][C:5]([NH:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:4][N:3]=1.[C:15]1([CH2:21][C:22](Cl)=[O:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>N1C=CC=CC=1>[C:9]1([CH2:8][N:7]([C:5]2[S:6][C:2]([CH3:1])=[N:3][N:4]=2)[C:22](=[O:23])[CH2:21][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 7679Phenylacetyl chlorideHCID 6460923N-benzyl-5-methyl-1,3,4-thiadiazol-2-amine

생성물 1

HCID 5324449HCID 5324449, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

N-(5-Methyl-1,3,4-thiadiazol-2-yl)-benzylamine (15 g, 0.073 mole) in pyridine (200 ml) was refluxed with phenylacetyl chloride for 6 hours. The pyridine was removed under educed pressure and the residue treated with water and extracted with ether. The ethereal solution was dried, filtered and evaporated to dryness and the residue recrystallised from ethanol to give the title compound, m.p. 128° C.

후처리

  1. customThe pyridine was removed
  2. additionthe residue treated with water
  3. extractionextracted with ether
  4. customThe ethereal solution was dried
  5. filtrationfiltered
  6. customevaporated to dryness
  7. customthe residue recrystallised from ethanol

출처 및 근거

ORD 기록
ord-db2c07feefb048ee9746aa08d6125d3f
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04158659

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