1-Hydroxybenzotriazole → HCID 178516355, 화합물

HRID 2368982노트

반응식

HRID 2368982 반응식
[C:1]1([C:7]2[N:12]=[CH:11][C:10]([C:13]3[CH:14]=[N:15][N:16]4[C:21]5[NH:22][CH2:23][CH2:24][C:25](=[O:26])[C:20]=5[C:19]([CH:27]5[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]5)=[N:18][C:17]=34)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:33]1[CH:37]=[N:36][C:35]([C:38](O)=[O:39])=[N:34]1.C1C=CC2N(O)N=NC=2C=1.CCN(C(C)C)C(C)C>CN(C=O)C.C(Cl)CCl>[N:33]1[N:34]=[C:35]([C:38]([N:30]2[CH2:31][CH2:32][CH:27]([C:19]3[C:20]4[C:25](=[O:26])[CH2:24][CH2:23][NH:22][C:21]=4[N:16]4[N:15]=[CH:14][C:13]([C:10]5[CH:11]=[N:12][C:7]([C:1]6[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=6)=[CH:8][CH:9]=5)=[C:17]4[N:18]=3)[CH2:28][CH2:29]2)=[O:39])[NH:36][CH:37]=1

참가 물질

7

반응물 4

HCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 1361688203-(6-phenylpyridin-3-yl)-5-(piperidin-4-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-oneHCID 178524907HCID 178524907, 화합물

생성물 1

HCID 178516355HCID 178516355, 화합물

시약·촉매·용매 2

HCID 111,2-Dichloroethane용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 3-(6-phenylpyridin-3-yl)-5-(piperidin-4-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one (70 mg, 0.17 mmoL), 1H-1,2,4-triazole-3-carboxylic acid (20.5 mg, 0.18 mmoL), EDC (63 mg, 0.33 mmoL), HOBt (44.6 mg, 0.33 mmoL) and DIEA (172.2 uL, 0.99 mmoL) in DMF (3 mL) was stirred at room temperature for 2 h. Purification with prep-LC provided 5-(1-(4H-1,2,4-triazole-3-carbonyl)piperidin-4-yl)-3-(6-phenylpyridin-3-yl)-8,9-dihydropyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-6(7H)-one: LCMS tR=3.15 Min (10 min run, UV254nm). Mass calculated for, M+ 519.2, observed LC/MS m/z 519.97 (M+H).

후처리

  1. customPurification

출처 및 근거

ORD 기록
ord-b0113471547e42eea094b58ccc592322
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08703784B2

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