Sodium borohydride → N-[4-(2-bromo-1-hydroxyethyl)phenyl]acetamide
반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)=[O:4].[BH4-].[Na+]>C(OCC)C.O>[Br:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)[OH:4]참가 물질
5
실험 절차
To a solution of N-[4-(2-bromoacetyl)phenyl]acetamide (2.1 g, 0.0082 mol, in 30 mL of methanol) was introduced solid NaBH4 (1.0 g, 0.026 mol) at 0° C. and stirred at that temperature for 15 minutes. The mixture was diluted with diethyl ether (20 mL) and water (20 mL). The ether phase was separated and the aqueous phase was extracted with diethyl ether. The ether phases were combined and washed with brine, dried. Purification on a silica gel column gave the title compound as a white solid (0.40 g).
후처리
- customThe ether phase was separated
- extractionthe aqueous phase was extracted with diethyl ether
- washwashed with brine
- customdried
- customPurification on a silica gel column
출처 및 근거
- ORD 기록
- ord-8ad6315898104647b2eb53bf2349ec6b
- 출처 데이터셋
- uspto-grants-2005_02
- 특허 번호
- US06852731B2
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