Hydrochloric Acid → HCID 20304505, 화합물

HRID 236961노트

반응식

HRID 236961 반응식
[CH3:1][C:2]1[C:3](=[O:24])[C:4]2[CH:20]=[C:19]3[C:14]([CH2:15][CH2:16][CH2:17][CH2:18]3)=[C:13]([CH2:21][CH2:22][CH3:23])[C:5]=2[O:6][C:7]=1[C:8]([O:10]CC)=[O:9].Cl>C(O)(=O)C>[CH3:1][C:2]1[C:3](=[O:24])[C:4]2[CH:20]=[C:19]3[C:14]([CH2:15][CH2:16][CH2:17][CH2:18]3)=[C:13]([CH2:21][CH2:22][CH3:23])[C:5]=2[O:6][C:7]=1[C:8]([OH:10])=[O:9]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 20304565HCID 20304565, 화합물

생성물 1

HCID 20304505HCID 20304505, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of the product of step (f) (16.2 g), glacial acetic acid (80 ml) and 5 N hydrochloric acid (20 ml) was heated and stirred on a steam bath overnight, and then evaporated. The residue was extracted with aqueous sodium bicarbonate and the extract was filtered and then acidified. Precipitated material was isolated by decantation and was triturated with water, dried, then triturated with an ether/petroleum ether (40°-60°) mixture. There remained as an insoluble off-white solid, 6,7,8,9-tetrahydro-3-methyl-4-oxo-10-propyl-4H-naphtho[2,3-b]pyran-2-carboxylic acid, (3.5 g), m.p 162°-4°.

후처리

  1. temperaturewas heated
  2. customevaporated
  3. extractionThe residue was extracted with aqueous sodium bicarbonate
  4. filtrationthe extract was filtered
  5. customPrecipitated material was isolated by decantation
  6. customwas triturated with water
  7. customdried
  8. customtriturated with an ether/petroleum ether (40°-60°) mixture
  9. customremained as an insoluble off-white solid, 6,7,8,9-tetrahydro-3-methyl-4-oxo-10-propyl-4H-naphtho[2,3-b]pyran-2-carboxylic acid, (3.5 g), m.p 162°-4°

출처 및 근거

ORD 기록
ord-32a39b1926d9437db97756beeb7c2a2c
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04159273

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