Potassium Hydroxide → 1-(3-Chlorophenyl)piperazine

HRID 237025

반응식

HRID 237025 반응식
[N+](C1C=CC(S([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=3)[CH2:15][CH2:14]2)(=O)=O)=CC=1)([O-])=O.[OH-].[NH4+].[OH-].[K+]>CCOCC.[Cl-].[Cl-].[Cl-].[Ti+3]>[Cl:25][C:21]1[CH:20]=[C:19]([N:16]2[CH2:17][CH2:18][NH:13][CH2:14][CH2:15]2)[CH:24]=[CH:23][CH:22]=1

참가 물질

6

반응물 3

HCID 14797Potassium HydroxideHCID 14923Ammonium HydroxideHCID 10197251-(3-Chlorophenyl)-4-(4-nitrophenyl)sulfonylpiperazine

생성물 1

HCID 13551-(3-Chlorophenyl)piperazine

시약·촉매·용매 2

HCID 10313229titanium(III) trichloride촉매HCID 3283Diethyl Ether용매

실험 절차

1-[(p-Nitrophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine is reduced with aqueous titanium trichloride in ether solution by dropwise addition of aqueous TiCl3 until the purple color is no longer discharged. The reaction progress is followed by thin layer chromatography. Work-up with concentrated ammonium hydroxide and subsequently aqueous potassium hydroxide followed by isolation, drying, and concentration of the organic layer gives 1-[p-aminophenyl)sulfonyl]-4-(m-chlorophenyl)piperazine.

후처리

  1. customdrying

출처 및 근거

ORD 기록
ord-abb38bd69cbe41e4b74d1fd6d4d564b2
출처 데이터셋
uspto-grants-1979_06
특허 번호
US04159331

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