Hydrochloric Acid → HCID 53260305, 화합물

HRID 2370341노트

반응식

HRID 2370341 반응식
C(OC(=O)[NH:7][C@H:8]([C:12](=[O:49])[NH:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([CH:22]2[CH2:27][CH2:26][N:25]([C:28]([C:30]3[C:38]4[C:33](=[C:34]([F:44])[CH:35]=[CH:36][C:37]=4[O:39][C:40]([F:43])([F:42])[F:41])[N:32]([CH2:45][CH2:46][O:47][CH3:48])[CH:31]=3)=[O:29])[CH2:24][CH2:23]2)[CH:16]=1)[CH:9]([CH3:11])[CH3:10])(C)(C)C.[ClH:51]>CCOCC>[ClH:51].[NH2:7][C@@H:8]([CH:9]([CH3:11])[CH3:10])[C:12]([NH:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[C:17]([CH:22]2[CH2:27][CH2:26][N:25]([C:28]([C:30]3[C:38]4[C:33](=[C:34]([F:44])[CH:35]=[CH:36][C:37]=4[O:39][C:40]([F:41])([F:42])[F:43])[N:32]([CH2:45][CH2:46][O:47][CH3:48])[CH:31]=3)=[O:29])[CH2:24][CH2:23]2)[CH:16]=1)=[O:49]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68228638HCID 68228638, 화합물

생성물 1

HCID 53260305HCID 53260305, 화합물수율 82%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a solution of [(S)-1-(4-fluoro-3-{1-[7-fluoro-1-(2-methoxy-ethyl)-4-trifluoromethoxy-1H-indole-3-carbonyl]-piperidin-4-yl}-benzylcarbamoyl)-2-methyl-propyl]-carbamic acid tert-butyl ester (0.35 g, 0.49 mmol) in ether (20 mL) was added 2M HCl in ether (10 mL, 20.0 mmol). The reaction mixture was stirred at rt overnight. The resulting precipitate was collected to give the titled compound (260 mg, 82%). 1H NMR (300 MHz, DMSO-d6) δ 9.0 (m, 1H), 8.3 (bs, 2H), 7.7 (s, 1H), 7.3-7.0 (m, 5H), 4.5 (m, 2H), 4.4-4.2 (m, 2H), 3.7-3.5 (m, 6H), 3.2 (s, 3H), 3.1-2.9 (m, 2H), 2.1 (m, 1H), 1.85-1.5 (m, 4H), 0.9 (m, 6H). MS m/z: [M+H]+=611.

후처리

  1. customThe resulting precipitate was collected

출처 및 근거

ORD 기록
ord-1787fa5e990647f2ac475e81de4b04eb
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08710080B2

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