N-methyl-4-(2-(methylsulfinyl)benzo[d]oxazol-6-yloxy)picolinamide → 4-{2-[1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-ethylamino]-benzooxazol-6-yloxy}-pyridine-2-carboxylic acid methylamide

HRID 2370510

반응식

HRID 2370510 반응식
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([CH:11]([NH2:13])[CH3:12])[C:5]=2[O:4][CH2:3][CH2:2]1.[CH3:14][NH:15][C:16]([C:18]1[CH:23]=[C:22]([O:24][C:25]2[CH:36]=[CH:35][C:28]3[N:29]=[C:30](S(C)=O)[O:31][C:27]=3[CH:26]=2)[CH:21]=[CH:20][N:19]=1)=[O:17]>C1COCC1>[CH3:14][NH:15][C:16]([C:18]1[CH:23]=[C:22]([O:24][C:25]2[CH:36]=[CH:35][C:28]3[N:29]=[C:30]([NH:13][CH:11]([C:10]4[C:5]5[O:4][CH2:3][CH2:2][O:1][C:6]=5[CH:7]=[CH:8][CH:9]=4)[CH3:12])[O:31][C:27]=3[CH:26]=2)[CH:21]=[CH:20][N:19]=1)=[O:17]

참가 물질

4

반응물 2

HCID 57725414N-methyl-4-(2-(methylsulfinyl)benzo[d]oxazol-6-yloxy)picolinamideHCID 577255011-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-ethylamine

생성물 1

HCID 577255794-{2-[1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-ethylamino]-benzooxazol-6-yloxy}-pyridine-2-carboxylic acid methylamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-ethylamine (3 eq) in THF was added 4-(2-methanesulfinyl-benzooxazol-6-yloxy)-pyridine-2-carboxylic acid methylamide (1 eq). This was stirred at room temperature for 8 hours, concentrated and the residue was purified by preparatory reverse phase HPLC. MH+=447.1.

후처리

  1. concentrationconcentrated
  2. customthe residue was purified by preparatory reverse phase HPLC

출처 및 근거

ORD 기록
ord-e97f334a6cfa450b8285ab30fdd4d2f4
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08710048B2

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