Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 3-oxo-2-(2-phenylethyl)butanoate → 5-(2-Phenylethyl)-6-methyl-2-thiouracil
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 3-oxo-2-(2-phenylethyl)butanoate | HCID 219459 | — |
| 반응물 | Thiourea | HCID 2723790 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-(2-Phenylethyl)-6-methyl-2-thiouracil | HCID 12945970 | — |
반응 단계
Ethyl α-(phenylethyl)acetoacetate (23.4 g) and thiourea (10.65 g) were added to a solution of sodium ethoxide in ethanol (100 ml) prepared from sodium (4.6 g). The mixture was refluxed for 51/2 hours and evaporated to dryness. The solid residue was dissolved in water and acetic acid was added to pH 4. The white precipitate was filtered off and recrystallised from ethanol to give 5-(2-phenylethyl)-6-methyl-2-thiouracil m.p. 210°-214°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04159329 |
| 출처 데이터셋 | uspto-grants-1979_06 |
| ORD ID | ord-4af3bbe7023a4bd1bc4c638c8bdf57ba |
| 출처 메모 | uspto-grants-1979_06 |