Hydrochloric Acid → Isopropyl 3-(6-aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionate

HRID 2370913노트

반응식

HRID 2370913 반응식
Cl.Cl.[NH2:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][CH:11]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:19]=2)[C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1.[CH:26](O)([CH3:28])[CH3:27]>>[NH2:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][CH:11]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:19]=2)[C:12]([O:14][CH:26]([CH3:28])[CH3:27])=[O:13])=[CH:6][CH:5]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 694540453-(6-Aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionic acid hydrochloride

생성물 1

HCID 69250787Isopropyl 3-(6-aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionate

실험 절차

2 ml of an HCl-saturated ether solution were added to a solution of 38.0 mg (0.12 mmol) of the compound from example 1i in 5 ml of isopropanol and stirred at RT for 4 h. The solution was then concentrated to dryness, and the resulting residue was dried under high vacuum. 25 mg of the title compound resulted as bishydrochloride in the form of an amorphous solid.

후처리

  1. concentrationThe solution was then concentrated to dryness
  2. customthe resulting residue was dried under high vacuum

출처 및 근거

ORD 기록
ord-edcee3a85f99416b94a67229783cb20f
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08710232B2

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