Hydrochloric Acid → Cyclopropylmethyl 3-(6-aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionate

HRID 2370914노트

반응식

HRID 2370914 반응식
Cl.Cl.[NH2:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][CH:11]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:19]=2)[C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1.[CH:26]1([CH2:29]O)[CH2:28][CH2:27]1>>[NH2:3][C:4]1[N:9]=[CH:8][C:7]([CH2:10][CH:11]([C:15]2[N:16]=[CH:17][N:18]([CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)[CH:19]=2)[C:12]([O:14][CH2:29][CH:26]2[CH2:28][CH2:27]2)=[O:13])=[CH:6][CH:5]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 75644CyclopropanemethanolHCID 694540453-(6-Aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionic acid hydrochloride

생성물 1

HCID 11516183Cyclopropylmethyl 3-(6-aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-4-yl)propionate

실험 절차

1 ml of an HCl-saturated ether solution was added to a solution of 50.0 mg (0.16 mmol) of the compound from example 1i in 2 ml of cyclopropylcarbinol and stirred at room temperature for 12 h. The solution was then concentrated to dryness, and the resulting residue was dried under high vacuum. Purification by chromatography on silica gel with CH2Cl2/methanol as mobile phase afforded 29 mg of the title compound in the form of an amorphous solid.

후처리

  1. concentrationThe solution was then concentrated to dryness
  2. customthe resulting residue was dried under high vacuum
  3. customPurification by chromatography on silica gel with CH2Cl2/methanol as mobile phase

출처 및 근거

ORD 기록
ord-30f14c5a0401438faba89436db54bfef
출처 데이터셋
uspto-grants-2014_04
특허 번호
US08710232B2

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