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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Sodium Iodide → HCID 57656859, 화합물

HRID 2371182
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HRID 2371182 반응식
CS(O[CH2:6][C@@H:7]1[O:12][CH2:11][CH2:10][N:9]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:8]1)(=O)=O.[I-].[Na+].C(=O)([O-])[O-].[K+].[K+].[CH2:28]([O:35][C:36]([N:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1)=[O:37])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>C(#N)CCC.CCCC(C)C.C(OCC)(=O)C.O>[CH2:28]([O:35][C:36]([N:38]1[CH2:43][CH2:42][N:41]([CH2:6][C@@H:7]2[O:12][CH2:11][CH2:10][N:9]([C:13]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:14])[CH2:8]2)[CH2:40][CH2:39]1)=[O:37])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

9

반응물 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 643495Benzyl piperazine-1-carboxylateHCID 57686771HCID 57686771, 화합물

생성물 1

HCID 57656859HCID 57656859, 화합물수율 70%

시약·촉매·용매 4

HCID 962Water용매
HCID 7892
2-Methylpentane
용매
HCID 8008Butyronitrile용매
HCID 8857Ethyl Acetate용매2회

실험 절차

tert-Butyl (2R)-2-{[(methylsulfonyl)oxy]methyl}morpholine-4-carboxylate (75 g, 0.25 mol), sodium iodide (11.4 g, 76 mmol), potassium carbonate (38 g, 0.28 mol) and benzyl-1-piperazine carboxylate (54 mL, 0.28 mol) were heated together in butyronitrile (1.5 L) at 115° C. for 24 hours. Water (1.8 L) was added and the layers separated, the aqueous phase was washed with ethyl acetate (1 L) and the combined organics were washed with brine (1 L), dried (MgSO4) and evaporated to give crude product as a yellow oil. Chromatography (5 kg column: 20% ethyl acetate to 50% ethyl acetate in isohexane) gave product as pale yellow gum (73 g, 0.17 mol, 70%).

후처리

  1. customthe layers separated
  2. washthe aqueous phase was washed with ethyl acetate (1 L)
  3. washthe combined organics were washed with brine (1 L)
  4. dry with materialdried (MgSO4)
  5. customevaporated
  6. customto give crude product as a yellow oil

출처 및 근거

ORD 기록
ord-6fd6d579db264abf990a149e90b3a63f
출처 데이터셋
uspto-grants-2014_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08710224B2

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