Ethyl 5-Amino-8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate → 5-Amino-8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid

HRID 2372082노트

반응식

HRID 2372082 반응식
[NH2:1][C:2]1[C:11]([F:12])=[C:10]([F:13])[C:9]([Cl:14])=[C:8]2[C:3]=1[C:4](=[O:23])[C:5]([C:18]([O:20]CC)=[O:19])=[CH:6][N:7]2[CH:15]1[CH2:17][CH2:16]1>Cl>[NH2:1][C:2]1[C:11]([F:12])=[C:10]([F:13])[C:9]([Cl:14])=[C:8]2[C:3]=1[C:4](=[O:23])[C:5]([C:18]([OH:20])=[O:19])=[CH:6][N:7]2[CH:15]1[CH2:16][CH2:17]1

참가 물질

3

반응물 1

HCID 15052639Ethyl 5-Amino-8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

생성물 1

HCID 148965465-Amino-8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid수율 89.9%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A suspension of 17.2 g (50.2 mmol) of ethyl 5-amino-8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate in 100 ml of 6M hydrochloric acid was refluxed for three hours. The mixture was cooled to room temperature, and the solids were filtered, washed with water and ether, and dried to give 14.2 g of the title compound.

후처리

  1. temperaturewas refluxed for three hours
  2. filtrationthe solids were filtered
  3. washwashed with water and ether
  4. customdried

출처 및 근거

ORD 기록
ord-ea90a57899c1486783261dc2faf3bd1b
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05097032

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