Water → ethyl N-(2-fluorophenyl)carbamate

HRID 2372208노트

반응식

HRID 2372208 반응식
[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].Cl[C:10]([O:12][CH2:13][CH3:14])=[O:11].[OH-].[Na+].O>CCOCC>[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:10](=[O:11])[O:12][CH2:13][CH3:14]

참가 물질

6

반응물 4

HCID 962WaterHCID 95842-FluoroanilineHCID 10928Ethyl chloroformate2회HCID 14798Sodium Hydroxide

생성물 1

HCID 242730ethyl N-(2-fluorophenyl)carbamate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a solution of 2-fluoroaniline (11.1 g, 100.0 mmol) in 100 ml of dry ether cooled in an ice bath is added ethyl chloroformate (7.1 ml, 8.1 g, 75.0 mmol). After addition, the mixture is allowed to warm to RT and is stirred at RT for 3 hours. Then a 10% sodium hydroxide solution (54 ml, 2.8M, 150.0 mmol) is added, followed by another 7.1 ml of ethyl chloroformate. The mixture is stirred at RT for 3 hours, and is then poured into water and ether. The organic layer is separated, washed with 5% HCl and with brine, and dried. The solvent is removed to give ethyl N-(2-fluorophenyl)carbamate.

후처리

  1. additionAfter addition
  2. stirringThe mixture is stirred at RT for 3 hours
  3. customThe organic layer is separated
  4. washwashed with 5% HCl and with brine
  5. customdried
  6. customThe solvent is removed

출처 및 근거

ORD 기록
ord-35b1058271fe4787be2346219ff142a1
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05098466

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