Hydrochloric Acid → 2-(1H-imidazol-1-ylmethyl)cyclopentanone

반응식

C1O[C:4]2([CH2:8][CH2:7][CH2:6][CH:5]2[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)[O:3]C1.Cl.[OH-].[K+]>>[N:10]1([CH2:9][CH:5]2[CH2:6][CH2:7][CH2:8][C:4]2=[O:3])[CH:14]=[CH:13][N:12]=[CH:11]1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 14797Potassium Hydroxide

HCID 108460442-(lH-imidazol-1-ylmethyl)cyclopentanone ethyleneketal

생성물 1

HCID 107021672-(1H-imidazol-1-ylmethyl)cyclopentanone

반응 조건

온도: 60 °C

실험 절차

In an oil bath, 3.5603 g of 2-(lH-imidazol-1-ylmethyl)cyclopentanone ethyleneketal (IV) and 17.8 ml of 2N hydrochloric acid added thereto were stirred at 60° C for 5 hours. The resultant reaction solution was left cooling. Then, it was neutralized with an aqueous lN potassium hydroxide solution and extracted with methylene chloride, to obtain an organic layer. This organic layer was washed with water, dried over anhydrous sodium sulfate, and evaporated under a reduced pressure.