4-Hydroxybenzaldehyde → Benzaldehyde, 3-(chloromethyl)-4-hydroxy-

반응식

[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[ClH:10].[CH2:11]=O>>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[CH2:11][Cl:10]

참가 물질

반응물 3

HCID 1264-Hydroxybenzaldehyde

HCID 313Hydrochloric Acid

HCID 712Formaldehyde

생성물 1

HCID 7140230Benzaldehyde, 3-(chloromethyl)-4-hydroxy-

실험 절차

Through a well-stirred suspension of 0.1 mole 4-hydroxybenzaldehyde, 88ml concentrated HCl and 8.8ml 37% aqueous formaldehyde was bubbled HCl gas for approximately 4 hours. A product had fallen out of solution. The reaction mixture was refrigerated for 1.5 hours and then the product was isolated on a scintered-glass funnel and washed with a total of 1 liter cold water. mp 123°-124° C.