Hydrochloric Acid → Pyrrolidine, 2-[(3,4-dimethoxyphenyl)methyl]-, (R)-

HRID 2372833노트

반응식

HRID 2372833 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:18]=[CH:19][C:20]=1[O:21][CH3:22])[CH2:6][C@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1C(=O)C(F)(F)F.Cl>C(O)(C)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:18]=[CH:19][C:20]=1[O:21][CH3:22])[CH2:6][C@H:7]1[CH2:11][CH2:10][CH2:9][NH:8]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 13330057HCID 13330057, 화합물

생성물 1

HCID 11831008Pyrrolidine, 2-[(3,4-dimethoxyphenyl)methyl]-, (R)-수율 97%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To a solution of (R)-2-(3,4-dimethoxybenzyl)-1-trifluoroacetylpyrrolidine (3.2 g, 0.010 mol) in 50 mL isopropyl alcohol was added 15 mL of 12.5M HCl. The mixture was then heated under reflux until all starting material had disappeared, approximately 24 hours. The solvent was removed in vacuo to give an oil which could be recrystallized from isopropyl alcohol/ether, giving 2.5 of (R)-2-(3,4-dimethoxybenzyl)pyrrolidine (97% yield), as needles, m.p. 165°-167° C.

후처리

  1. temperatureThe mixture was then heated
  2. temperatureunder reflux until all starting material
  3. customThe solvent was removed in vacuo
  4. customto give an oil which
  5. customcould be recrystallized from isopropyl alcohol/ether

출처 및 근거

ORD 기록
ord-b0d519e2282c48aeb0053a70021d26b5
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05100912

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