Phosphorus oxychloride → 2-Butyl-4-chloro-6-methylpyrimidine

반응식

[CH2:1]([C:5]1[NH:10][C:9](=O)[CH:8]=[C:7]([CH3:12])[N:6]=1)[CH2:2][CH2:3][CH3:4].P(Cl)(Cl)([Cl:15])=O>>[CH2:1]([C:5]1[N:10]=[C:9]([Cl:15])[CH:8]=[C:7]([CH3:12])[N:6]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 1354243772-Butyl-6-methyl-4-pyrimidinol

생성물 1

HCID 176064082-Butyl-4-chloro-6-methylpyrimidine

실험 절차

The pyrimidinone from Example 3 2-n-butyl-6-methylpyrimidin-4(3H)-one is converted to the title compound upon treatment with phosphoryl chloride as described by Gabriel amd Colman (Ber. 1899, 32, 2921) and by Marshall and Walker (J. Chem. Soc., 1951, 1004).

출처 및 근거

ORD 기록: ord-4c1862e115cb4fe79b223dce9e83a049
출처 데이터셋: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05100897

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