1,1',1''-(Chlorosilylidyne)tris(benzene) → (9H-Fluoren-9-yl)(triphenyl)silane

HRID 2373083노트

반응식

HRID 2373083 반응식
[CH:1]1[C:13]2[CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.C([Li])CCC.[C:19]1([Si:25](Cl)([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CCOCC.C1C=CC=CC=1>[C:32]1([Si:25]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:12]2[C:11]3[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=3[C:5]3[C:13]2=[CH:1][CH:2]=[CH:3][CH:4]=3)[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

참가 물질

6

반응물 3

HCID 64581,1',1''-(Chlorosilylidyne)tris(benzene)HCID 6853FluoreneHCID 178418339Butyllithium

생성물 1

HCID 12666783(9H-Fluoren-9-yl)(triphenyl)silane수율 98.9%

시약·촉매·용매 2

HCID 241Benzene용매HCID 3283Diethyl Ether용매

실험 절차

To a solution of 17 g of fluorene (102.4 mmol) in 300 mL of dry ether was added 46 mL of 2.3M n-butyllithium dropwise over a period of 20 minutes. The mixture was refluxed for 3 hours, cooled in an ice bath, and treated in one portion with a solution of 24 g (81.46 mmol) of triphenylsilyl chloride in 100 mL of dry benzene. The mixture was refluxed for 24 hours, cooled to room temperature, and washed with sat'd NH4Cl (100 mL), brine (150 mL), and water (150 mL). The organic layer was dried over MgSO4 and the solvent was evaporated in vacuo to give a yellow residue which was triturated with methanol to afford 34.18 g (98.9%) of the crude silane as an off-white solid. Recrystallization from EtOAc--EtOH (4:1) gave 27.46 g (79.5%) of the pure triphenylsilane as white needles, m.p. 182°-193° C.; 1H NMR (CDCl3): δ 4.72 (s, 1H, CH), 6.82-7.90 (m, 23H, aryl).

후처리

  1. temperatureThe mixture was refluxed for 3 hours
  2. temperaturecooled in an ice bath
  3. temperatureThe mixture was refluxed for 24 hours
  4. washwashed with sat'd NH4Cl (100 mL), brine (150 mL), and water (150 mL)
  5. dry with materialThe organic layer was dried over MgSO4
  6. customthe solvent was evaporated in vacuo
  7. customto give a yellow residue which
  8. customwas triturated with methanol

출처 및 근거

ORD 기록
ord-795702c0abd543f682068277b16f7895
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05101059

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