Dimethylformamide → 4-Chloro-7-nitroquinazoline

HRID 237316

반응식

HRID 237316 반응식
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([C:8](=O)[NH:9][CH:10]=[N:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].CN(C=O)C.S(Cl)([Cl:22])=O>>[Cl:22][C:8]1[C:7]2[C:12](=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[N:11]=[CH:10][N:9]=1

참가 물질

4

반응물 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 862228007-Nitroquinazolin-4(3H)-one

생성물 1

HCID 8306804-Chloro-7-nitroquinazoline

실험 절차

To a solution of 7-nitroquinazolin-4(3H)-one (2.0 g, 10.5 mmol) in 40 ml thionyl chloride was added 0.8 ml of DMF and the mixture was heated at reflux overnight then evaporated to dryness to provide crude 4-chloro-7-nitroquinazoline.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux overnight
  3. customthen evaporated to dryness

출처 및 근거

ORD 기록
ord-f0f7d6401cd4487e98e4fe40bbd46dba
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642582B2

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