Hydrochloric Acid → Methyl 2-amino-5-methoxybenzoate

HRID 2373351

반응식

HRID 2373351 반응식
Cl.[NH2:2][C:3]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[CH3:14]O>>[NH2:2][C:3]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:4]=1[C:5]([O:7][CH3:14])=[O:6]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2779305-Methoxyanthranilic acid

생성물 1

HCID 13052275Methyl 2-amino-5-methoxybenzoate

반응 조건

온도
60 °C

실험 절차

Hydrogen chloride gas was bubbled through a solution of 2-amino-5-methoxybenzoic acid (5.0 g, 30 mmol) in MeOH (200 mL) for 30 minutes. The solution was heated at 60° C. overnight. The reaction was cooled and the solvent removed in vacuo. The residue was dissolved in water, basified with 5M NaOH and extracted twice with ether. The ether extracts were washed with 5M NaOH and water, dried (MgSO4), filtered and concentrated in vacuo to give i-e (4.25 g, 78%): MS m/z═182 (M+H).

후처리

  1. temperatureThe reaction was cooled
  2. customthe solvent removed in vacuo
  3. dissolutionThe residue was dissolved in water
  4. extractionextracted twice with ether
  5. washThe ether extracts were washed with 5M NaOH and water
  6. dry with materialdried (MgSO4)
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo
  9. customto give i-e (4.25 g, 78%)

출처 및 근거

ORD 기록
ord-485b0003c27d4732bd3d76857f9246f2
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07459448B2

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