Potassium Carbonate → 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester

HRID 2373852

반응식

HRID 2373852 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([CH2:11]Br)=[CH:7][N:6]=1)=[O:4].[F:13][C:14]([F:24])([F:23])[O:15][C:16]1[CH:17]=[C:18]([OH:22])[CH:19]=[CH:20][CH:21]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([CH2:11][O:22][C:18]2[CH:19]=[CH:20][CH:21]=[C:16]([O:15][C:14]([F:13])([F:23])[F:24])[CH:17]=2)=[CH:7][N:6]=1)=[O:4]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 27332613-(Trifluoromethoxy)phenolHCID 21973569Methyl 5-(bromomethyl)pyrazine-2-carboxylate

생성물 1

HCID 692063465-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester수율 88.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 5-bromomethyl-pyrazine-2-carboxylic acid methyl ester (0.305 g, 1.314 mmol) in DMF (6 mL) was treated with 3-trifluoromethoxyphenol (0.280 g, 1.577 mmol) and potassium carbonate (0.400 g, 2.89 mmol) by the general procedure G. The crude product was purified by flash column chromatography on silica gel to give 0.380 g of pure 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester. LCMS: 330 (M+2)+

후처리

  1. customThe crude product was purified by flash column chromatography on silica gel

출처 및 근거

ORD 기록
ord-b547a5d1b0354d98b065c0720cf92894
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07459472B2

연결된 노트

불러오는 중…