Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hydroxide → 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester | HCID 69206346 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | MeOH tetrahydrofuran | HCID 21899815 | — |
| 생성물 | 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid | HCID 69208103 | 81.4% |
반응 단계
A solution of 5-(3-trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester (0.234 g, 0.712 mmol) in THF:MeOH (4:1, 5 mL) was treated with LiOH (0.150 g, 3.564 mmol) in 1.5 mL of water by the general procedure C to give 0.182 g of 5-(3-trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid. LCMS: 316 (M+2)+
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07459472B2 |
| 출처 데이터셋 | uspto-grants-2008_12 |
| ORD ID | ord-7492f68c66fc4f699500508db3bfc5dc |
| 출처 메모 | uspto-grants-2008_12 |