Lithium Hydroxide → 5-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid

HRID 2373853노트

반응식

HRID 2373853 반응식
C[O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=2)=[CH:7][N:6]=1)=[O:4].[Li+].[OH-]>C1COCC1.CO.O>[F:23][C:20]([F:21])([F:22])[O:19][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=1)[O:12][CH2:11][C:8]1[N:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=1

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 692063465-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester

생성물 1

HCID 692081035-(3-Trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid수율 81.4%

시약·촉매·용매 2

HCID 962Water용매HCID 21899815MeOH tetrahydrofuran용매

실험 절차

A solution of 5-(3-trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester (0.234 g, 0.712 mmol) in THF:MeOH (4:1, 5 mL) was treated with LiOH (0.150 g, 3.564 mmol) in 1.5 mL of water by the general procedure C to give 0.182 g of 5-(3-trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid. LCMS: 316 (M+2)+

출처 및 근거

ORD 기록
ord-7492f68c66fc4f699500508db3bfc5dc
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07459472B2

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