HRID2373853

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)c1cnc(COc2cccc(OC(F)(F)F)c2)cn1

HCID69206346

未命名化合物

PRODUCTS

生成物

结构：O=C(O)c1cnc(COc2cccc(OC(F)(F)F)c2)cn1

HCID69208103

未命名化合物

收率 81.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

溶剂HCID21899815

未命名化合物

PROCEDURE

实验过程

A solution of 5-(3-trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid methyl ester (0.234 g, 0.712 mmol) in THF:MeOH (4:1, 5 mL) was treated with LiOH (0.150 g, 3.564 mmol) in 1.5 mL of water by the general procedure C to give 0.182 g of 5-(3-trifluoromethoxy-phenoxymethyl)-pyrazine-2-carboxylic acid. LCMS: 316 (M+2)+