N-bromobutanimide → HCID 178448705, 화합물
반응식
[CH2:1]([N:5]1[C:13]2[NH:12][CH:11]=[N:10][C:9]=2[C:8]2=[N:14][N:15]=[CH:16][N:7]2[C:6]1=[O:17])[CH:2]([CH3:4])[CH3:3].[Br:18]N1C(=O)CCC1=O>C1COCC1>[Br:18][C:11]1[NH:12][C:13]2[N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[C:6](=[O:17])[N:7]3[CH:16]=[N:15][N:14]=[C:8]3[C:9]=2[N:10]=1참가 물질
4
실험 절차
To a solution of 6-isobutyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-i]purin-5-one (9.4 mg, 40 mmol) in THF (5 ml) was added N-bromosuccinimide (8 mg, 44.7 mmol). The mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated, and the residue was purified by preparative LCMS (method A) to provide the desired product. LCMS calculated for C10H12BrN6O (M+H): 311.0; found 310.9, 313.0.
후처리
- concentrationThe reaction mixture was concentrated
- customthe residue was purified by preparative LCMS (method A)
출처 및 근거
- ORD 기록
- ord-5c3cbfb1fbb24edcb60d120c097f8ccd
- 출처 데이터셋
- uspto-grants-2008_12
- 특허 번호
- US07462624B2
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