Benzoyl chloride → HCID 58711952, 화합물

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COC1C=CC(NC2N=NC(C(NC(C3OC=CC=3)=O)C)=CN=2)=CC=1.Cl.[CH3:27][S:28][C:29]1[N:30]=[N:31][C:32]([CH:35]([NH2:37])[CH3:36])=[CH:33][N:34]=1.[C:38](Cl)(=[O:45])[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1>>[CH3:27][S:28][C:29]1[N:30]=[N:31][C:32]([CH:35]([NH:37][C:38](=[O:45])[C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[CH3:36])=[CH:33][N:34]=1

참가 물질

반응물 3

HCID 7412Benzoyl chloride

HCID 58711967HCID 58711967, 화합물

HCID 68870503HCID 68870503, 화합물2회

생성물 1

HCID 58711952HCID 58711952, 화합물수율 83.4%

실험 절차

In a similar manner as described for Intermediate 59, using 1-[3-(Methylthio)-1,2,4-triazin-6-yl]ethanamine (Intermediate 4) (1.00 g, 5.90 mmol), benzoyl chloride (0.75 mL, 6.50 mmol), to give N-{1-[3-(methylthio)-1,2,4-triazin-6-yl]ethyl}benzamide (1.35 g) as a yellow solid. MS m/z 275 (M+1).

출처 및 근거

ORD 기록: ord-5b1626b02780440ebc5f7525db88d450
출처 데이터셋: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07462614B2

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