Hydrazine hydrate (1:1) → (2-Amino-5-ethoxyphenyl)methanol
반응식
[CH2:1]([O:3][C:4]1[CH:5]=[CH:6][C:7]([N+:12]([O-])=O)=[C:8]([CH2:10][OH:11])[CH:9]=1)[CH3:2].O.NN>CCO.[Pd]>[NH2:12][C:7]1[CH:6]=[CH:5][C:4]([O:3][CH2:1][CH3:2])=[CH:9][C:8]=1[CH2:10][OH:11]참가 물질
5
반응 조건
- 온도
- 90 °C
실험 절차
To a solution of (5-ethoxy-2-nitro-phenyl)-methanol (592 mg, 3.0 mmol) in absolute EtOH (20 mL) at rt was added 150 mg of Pd/C (Aldrich, 10 wt. % on active carbon), followed by slow addition of hydrazine hydrate (1.5 mL). The resulting reaction mixture was refluxed at 90° C. for 1 h. It was then cooled to rt, filtered through Celite, and then concentrated in vacuo to afford crude (2-amino-5-ethoxy-phenyl)-methanol as a pale yellow oil: MS (ESI) 168 (M+H)+.
후처리
- customThe resulting reaction mixture
- temperatureIt was then cooled to rt
- filtrationfiltered through Celite
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-338acb8f1d094b2a97e573b098bdf140
- 출처 데이터셋
- uspto-grants-2008_12
- 특허 번호
- US07465730B2
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