Sodium Hydroxide → 4-Chloro-6-iodo-7H-pyrrolo(2,3-d)pyrimidine

HRID 2375814노트

반응식

HRID 2375814 반응식
[Cl:1][C:2]1[C:3]2[CH:10]=[C:9]([I:11])[N:8](S(C3C=CC=CC=3)(=O)=O)[C:4]=2[N:5]=[CH:6][N:7]=1.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[C:3]2[CH:10]=[C:9]([I:11])[NH:8][C:4]=2[N:5]=[CH:6][N:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 574158854-Chloro-6-iodo-7-phenylsulfonyl-7H-pyrrolo[2,3-D]pyrimidine

생성물 1

HCID 457897324-Chloro-6-iodo-7H-pyrrolo(2,3-d)pyrimidine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 4-chloro-6-iodo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine (538 mg, 1.283 mmol) in THF (6.0 mL) was added 5 M sodium hydroxide methanolic solution (1.8 mL, 0.009 mmol). After 10 min the solvent was removed under reduced pressure, sat. ammonium chloride solution (5.0 mL) was added and the mixture evaporated to dryness. The resulting solid was triturated with water to afford 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine. 1H NMR (d6-DMSO, 400 MHz) 6.90(1H, s) and 8.55 (1H, s).

후처리

  1. customAfter 10 min the solvent was removed under reduced pressure, sat. ammonium chloride solution (5.0 mL)
  2. additionwas added
  3. customthe mixture evaporated to dryness
  4. customThe resulting solid was triturated with water

출처 및 근거

ORD 기록
ord-5c4292f5fdf44d3bbda0ba002cbe80b5
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07465726B2

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