2-Bromobenzenesulfonyl chloride → N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-bromobenzenesulfonamide

반응식

[NH2:1][C:2]1[C:7]([O:8][CH3:9])=[N:6][C:5]([CH3:10])=[CH:4][N:3]=1.[Br:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[S:18](Cl)(=[O:20])=[O:19]>>[CH3:9][O:8][C:7]1[C:2]([NH:1][S:18]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[Br:11])(=[O:20])=[O:19])=[N:3][CH:4]=[C:5]([CH3:10])[N:6]=1

참가 물질

반응물 2

HCID 5204032-Bromobenzenesulfonyl chloride

HCID 107018943-Methoxy-5-methyl-2-pyrazinamine

생성물 1

HCID 22574647N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-bromobenzenesulfonamide

실험 절차

2-amino-3-methoxy-5-methylpyrazine (1.50 g, 10.8 mmol; synthesized according to Bradbury, R. H., et. al. J. Med. Chem. 1997, 40, 996-1004) and 2-bromobenzenesulfonyl chloride (2.80 g, 11.0 mmol) were reacted according to the procedure of Example 25, Step A. 44A was a pink solid, 2.0 g (52%).

출처 및 근거

ORD 기록: ord-32684a7f2dc54df6a229f66d61bb8a06
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06852745B2

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