Sodium Hydroxide → 2-((S)-6-((R)-7-Fluoro-4-(4-(3-hydroxy-3-methylbutoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

HRID 237698노트

반응식

HRID 237698 반응식
[OH-].[Na+].[F:3][C:4]1[CH:5]=[CH:6][C:7]([C:28]2[C:33]([CH3:34])=[CH:32][C:31]([O:35][CH2:36][CH2:37][C:38]([OH:41])([CH3:40])[CH3:39])=[CH:30][C:29]=2[CH3:42])=[C:8]2[C:12]=1[C@H:11]([O:13][C:14]1[CH:27]=[CH:26][C:17]3[C@H:18]([CH2:21][C:22]([O:24]C)=[O:23])[CH2:19][O:20][C:16]=3[CH:15]=1)[CH2:10][CH2:9]2>CO>[F:3][C:4]1[CH:5]=[CH:6][C:7]([C:28]2[C:33]([CH3:34])=[CH:32][C:31]([O:35][CH2:36][CH2:37][C:38]([OH:41])([CH3:39])[CH3:40])=[CH:30][C:29]=2[CH3:42])=[C:8]2[C:12]=1[C@H:11]([O:13][C:14]1[CH:27]=[CH:26][C:17]3[C@H:18]([CH2:21][C:22]([OH:24])=[O:23])[CH2:19][O:20][C:16]=3[CH:15]=1)[CH2:10][CH2:9]2

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 86697111Methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-3-methylbutoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

생성물 1

HCID 717389952-((S)-6-((R)-7-Fluoro-4-(4-(3-hydroxy-3-methylbutoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1 M aqueous NaOH solution (420 μL) is added to a solution of methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-hydroxy-3-methylbutoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate (155 mg) in methanol (4 mL) at room temperature. The mixture is stirred at room temperature for 12 hours. The organic solvents are evaporated in vacuo. The residue is diluted with water and neutralized with 1 M aqueous HCl solution (420 μL). The mixture is stirred for 1 hour. The precipitate formed is filtered off, washed with water and dried in vacuo to give the title compound. Yield: 110 mg; LC (method 4): tR=1.85 min; Mass spectrum (ESI+): m/z=535 [M+H]+.

후처리

  1. customThe organic solvents are evaporated in vacuo
  2. additionThe residue is diluted with water and neutralized with 1 M aqueous HCl solution (420 μL)
  3. stirringThe mixture is stirred for 1 hour
  4. customThe precipitate formed
  5. filtrationis filtered off
  6. washwashed with water
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-fdd9576e9b8a47faa2e6d091e9fc5274
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642585B2

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