Sodium Hydroxide → 2-Amino-4'-fluorobenzophenone
반응식
CS(O)(=O)=O.[NH2:6][C:7]1[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)=[O:10].[OH-].[Na+]>ClC1C=CC=CC=1Cl>[NH2:6][C:7]1[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)=[O:10]참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
30 g of 2-amino-4′-fluorobenzophenone methanesulfonate was added to 150 g of o-dichlorobenzene, the resulting mixture was heated at 80° C. Then, the reaction solution was made alkaline with 25% aqueous solution of sodium hydroxide. The reaction solution was separated into phases at the same temperature and washed with 5% brine solution. The organic phase was dried over anhydrous magnesium sulfate, and filtered at 80° C. The filtrate was gradually cooled, stirred at 0 to 5° C. for 4 hours, filtered and washed with a small amount of toluene. After drying, 19 g of 2-amino-4′-fluorobenzophenone was obtained.