Sodium Hydroxide → 2-Amino-4'-fluorobenzophenone

HRID 23770

반응식

HRID 23770 반응식
CS(O)(=O)=O.[NH2:6][C:7]1[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)=[O:10].[OH-].[Na+]>ClC1C=CC=CC=1Cl>[NH2:6][C:7]1[CH:21]=[CH:20][CH:19]=[CH:18][C:8]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)=[O:10]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 53446970(2-Aminophenyl)(4-fluorophenyl)methanone methanesulfonate

생성물 1

HCID 98372872-Amino-4'-fluorobenzophenone수율 92%

시약·촉매·용매 1

HCID 72391,2-Dichlorobenzene용매

반응 조건

온도
80 °C

실험 절차

30 g of 2-amino-4′-fluorobenzophenone methanesulfonate was added to 150 g of o-dichlorobenzene, the resulting mixture was heated at 80° C. Then, the reaction solution was made alkaline with 25% aqueous solution of sodium hydroxide. The reaction solution was separated into phases at the same temperature and washed with 5% brine solution. The organic phase was dried over anhydrous magnesium sulfate, and filtered at 80° C. The filtrate was gradually cooled, stirred at 0 to 5° C. for 4 hours, filtered and washed with a small amount of toluene. After drying, 19 g of 2-amino-4′-fluorobenzophenone was obtained.

후처리

  1. customThe reaction solution was separated into phases at the same temperature
  2. washwashed with 5% brine solution
  3. dry with materialThe organic phase was dried over anhydrous magnesium sulfate
  4. filtrationfiltered at 80° C
  5. temperatureThe filtrate was gradually cooled
  6. filtrationfiltered
  7. washwashed with a small amount of toluene
  8. customAfter drying

출처 및 근거

ORD 기록
ord-eafd355cc1974afdb0be82430617665d
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852862B2

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