9-(4-Benzyloxy-phenyl)-bicyclo[3.3.1]nonan-9-ol → 9-(4-Benzyloxy-phenyl)-bicyclo[3.3.1]nonane

HRID 237763노트

반응식

HRID 237763 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2(O)[CH:20]3[CH2:21][CH2:22][CH2:23][CH:16]2[CH2:17][CH2:18][CH2:19]3)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCO.Cl>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]2[CH:20]3[CH2:21][CH2:22][CH2:23][CH:16]2[CH2:17][CH2:18][CH2:19]3)=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 670610079-(4-Benzyloxy-phenyl)-bicyclo[3.3.1]nonan-9-ol

생성물 1

HCID 685293519-(4-Benzyloxy-phenyl)-bicyclo[3.3.1]nonane수율 123.2%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

9-(4-Benzyloxy-phenyl)-bicyclo[3.3.1]nonan-9-ol (4.7 g, 14.57 mmol) (prepared in accordance with the procedures set forth in Step 2 of Example 18) was dissolved in EtOH (150 mL) after which concentrated hydrochloric acid (15 mL) was added. This mixture was stirred at 50° C. overnight. The solvent was removed under reduced pressure. Water (50 mL) was added. The mixture was basified with aqueous ammonia and extracted three times with EtOAc. The organic phase was dried and concentrated to provide the title compound (5.5 g).

후처리

  1. additionwas added
  2. customThe solvent was removed under reduced pressure
  3. additionWater (50 mL) was added
  4. extractionextracted three times with EtOAc
  5. customThe organic phase was dried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-73011340c21b43668ee6c3df638197a1
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642603B2

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