1-(4-Methoxyphenyl)-2-phenylethan-1-one → HCID 76529953, 화합물

HRID 2378066노트

반응식

HRID 2378066 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:5][CH:4]=1.Cl.[NH2:19][OH:20].C([O-])(=O)C.[Na+]>C(O)C.O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[N:19][OH:20])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:5][CH:4]=1

참가 물질

6

반응물 3

HCID 2310931-(4-Methoxyphenyl)-2-phenylethan-1-oneHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

생성물 1

HCID 76529953HCID 76529953, 화합물수율 87.9%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of the product of Step A, 1-(4-methoxy-phenyl)-2-phenyl-ethanone, (1011 g, 4468 mmoles) in absolute ethanol (2 gallons) is added hydroxylamine hydrochloride (373 g, 5362 mmoles) and sodium acetate (440 g, 5362 mmoles.) The reaction mixture is stirred at room temperature for two days. The mixture is diluted with water (8 L) and the resultant mixture is stirred at room temperature for one hour. The mixture is subsequently filtered to give a solid, which is rinsed with water (3×4 L.) The product is dried to afford the synthetic intermediate 1-(4-methoxy-phenyl)-2-phenyl-ethanone oxime (948 g.)

후처리

  1. filtrationThe mixture is subsequently filtered
  2. customto give a solid, which
  3. washis rinsed with water (3×4 L.) The product
  4. customis dried

출처 및 근거

ORD 기록
ord-35c47b316db24c0c83c960afb843120d
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07470715B2

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