Sodium Hydroxide → 3-(3-Fluoro-4-methoxyphenyl)propionic acid

HRID 2378531노트

반응식

HRID 2378531 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12]([O:14]CC)=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[OH-].[Na+]>CO>[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 22558762HCID 22558762, 화합물

생성물 1

HCID 30179663-(3-Fluoro-4-methoxyphenyl)propionic acid수율 92.2%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

A solution of Intermediate 8 (2.97 g) in methanol (40.0 ml) was added with 2 N aqueous sodium hydroxide (15.0 ml) and stirred at 60° C. for 16 hours. The reaction mixture was concentrated under reduced pressure, then made acidic with aqueous 5% hydrochloric acid under ice cooling, and extracted with ethyl acetate (200 ml). The organic layer was washed with saturated brine and dried, and then the solvent was evaporated under reduced pressure to obtain the title compound (Intermediate 9, 2.40 g).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. extractionextracted with ethyl acetate (200 ml)
  3. washThe organic layer was washed with saturated brine
  4. customdried
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-68de19d5683944119957a4a47c781761
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07470807B2

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