Sodium Hydroxide → 3-[4-methoxy-3-(naphthalen-2-yl)-5-nitrophenyl]Propionic Acid

HRID 2378545노트

반응식

HRID 2378545 반응식
FC1C=C(CCC(O)=O)C=CC=1OC.[CH3:15][O:16][C:17]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][C:20]([CH2:26][CH2:27][C:28]([O:30]C)=[O:29])=[CH:19][C:18]=1[C:32]1[CH:41]=[CH:40][C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:33]=1.[OH-].[Na+]>>[CH3:15][O:16][C:17]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][C:20]([CH2:26][CH2:27][C:28]([OH:30])=[O:29])=[CH:19][C:18]=1[C:32]1[CH:41]=[CH:40][C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:33]=1

참가 물질

4

반응물 3

HCID 14798Sodium HydroxideHCID 30179663-(3-Fluoro-4-methoxyphenyl)propionic acidHCID 22558707Methyl 3-[4-methoxy-3-(naphthalen-2-yl)-5-nitrophenyl]propionate

생성물 1

HCID 225591883-[4-methoxy-3-(naphthalen-2-yl)-5-nitrophenyl]Propionic Acid수율 83.2%

실험 절차

According to the procedure described in the synthesis method of Intermediate 9 provided that the reaction was carried out for 40 minutes, Intermediate 49 (2.45 g) and 2 N aqueous sodium hydroxide (6.7 ml) were reacted and treated to obtain the title compound (Intermediate 60, 1.96 g).

후처리

  1. customprovided that the reaction
  2. additiontreated

출처 및 근거

ORD 기록
ord-5b276a86dd30498f946cfe9287c171a8
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07470807B2

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