Methyl iodide → HCID 178483384, 화합물

HRID 2378711노트

반응식

HRID 2378711 반응식
[CH3:1][N:2]([CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][N:6]=1)[CH3:3].[CH3:14][I:15]>C(OCC)(=O)C>[I-:15].[NH:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]([CH2:4][N+:2]([CH3:14])([CH3:1])[CH3:3])=[N:6]1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 178483331(1H-Indazol-3-yl)-N,N-dimethylmethanamine

생성물 1

HCID 178483384HCID 178483384, 화합물수율 97.2%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

3-Dimethylaminomethyl-1H-indazole (25.6 g, 146 mmol) obtained in Step 2 was dissolved in ethyl acetate (350 mL), and the solution was added with methyl iodide (33.3 mL, 535 mmol), followed by stirring at room temperature overnight. The resulting precipitates were collected by filtration to obtain (1H-indazol-3-ylmethyl)trimethylammonium iodide (45.0 g, 97%).

후처리

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-9d51dc26137e4f4caa4ab489dba6e440
출처 데이터셋
uspto-grants-2008_12
특허 번호
US07470717B2

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