Lithium Hydroxide → HCID 15780556, 화합물

HRID 2379176노트

반응식

HRID 2379176 반응식
[C:1]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:10][C:11](=[O:15])[O:12]2)=[CH:7][CH:6]=1)([O:3]C)=[O:2].[Li+].[OH-].C1COCC1>CO>[C:16]1([C:9]2[C:8]3[C:13](=[CH:14][C:5]([C:1]([OH:3])=[O:2])=[CH:6][CH:7]=3)[O:12][C:11](=[O:15])[CH:10]=2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

5

반응물 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 15780555HCID 15780555, 화합물

생성물 1

HCID 15780556HCID 15780556, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 7-carbomethoxy-4-phenylcoumarin (510 mg), 1N LiOH (10 mL), THF (7 mL) and MeOH (10 mL) was heated at reflux for 1 hr. The solution was concentrated then H2O (10 mL), 1N HCl (15 mL), THF (10 mL) and Et2O (10 mL) were added and stirring continued for 1 hr. After this time, the organic layer was separated and concentrated to yield the title compound which was used as such in the next step.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 1 hr
  3. concentrationThe solution was concentrated
  4. additionH2O (10 mL), 1N HCl (15 mL), THF (10 mL) and Et2O (10 mL) were added
  5. customAfter this time, the organic layer was separated
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b74d08543fbb40539a6427af811bb6f3
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05360815

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