Hydrochloric Acid → Garomefrine Hydrochloride

HRID 2379194노트

반응식

C([C@@H]([C@H](C(O)=O)O)O)(O)=O.[NH2:11][CH2:12][C@@H:13]([C:15]1[CH:16]=[C:17]([CH:23]=[CH:24][C:25]=1[F:26])[NH:18][S:19]([CH3:22])(=[O:21])=[O:20])[OH:14].[ClH:27]>>[ClH:27].[NH2:11][CH2:12][C@@H:13]([C:15]1[CH:16]=[C:17]([CH:23]=[CH:24][C:25]=1[F:26])[NH:18][S:19]([CH3:22])(=[O:20])=[O:21])[OH:14]

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 86748228HCID 86748228, 화합물

생성물 1

HCID 9838762Garomefrine Hydrochloride

실험 절차

(R)-(-)-3'-(2-Amino-1-hydroxyethyl)-4'-fluoromethanesulfonanilide L-(+)-tartrate (2.0 g) was made into a free base using ion exchange resin (Dowex 50W X2) followed by treating with 20% ethanolic hydrochloric acid. The crystals which were separated out were collected to give 1.1 g of (R)-(-)-3'-(2-amino-1-hydroxyethyl)-4'-fluoromethanesulfonanilide hydrochloride, m.p. 189°-191° C.

후처리

customThe crystals which were separated out
customwere collected

출처 및 근거

ORD 기록: ord-c6e8fd5788f543059b628e5dd7039b3c
출처 데이터셋: uspto-grants-1994_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05360822

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