Methyl iodide → 1-methyl-2-(methylsulfanyl)-4,5-dihydro-1H-imidazole hydroiodide

HRID 237929노트

반응식

HRID 237929 반응식
[CH3:1][N:2]1[CH2:6][CH2:5][NH:4][C:3]1=[S:7].[CH3:8][I:9]>CC(C)=O>[IH:9].[CH3:1][N:2]1[CH2:6][CH2:5][N:4]=[C:3]1[S:7][CH3:8]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 2733224Methylethylenethiourea

생성물 1

HCID 122815051-methyl-2-(methylsulfanyl)-4,5-dihydro-1H-imidazole hydroiodide수율 77%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a suspension of 1-methylimidazolidine-2-thione (5.17 g, 44.5 mmol) in acetone (50 mL) was added MeI (2.9 mL, 46.6 mmol). The solution was allowed to stir at room temperature for 4 h and the resulting solid was quickly filtered and then dried in vacuo to give 1-methyl-2-(methylthio)-4,5-dihydro-1H-imidazole hydroiodide (8.79 g, 77%) as beige solid.

후처리

  1. filtrationthe resulting solid was quickly filtered
  2. customdried in vacuo

출처 및 근거

ORD 기록
ord-fdb60214d5144257b439b350e79df1cf
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08642025B2

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