Terazosin Hydrochloride → Terazosin

HRID 2379401

반응식

HRID 2379401 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]2[C:9]([NH2:26])=[N:10][C:11]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([CH:21]4[O:25][CH2:24][CH2:23][CH2:22]4)=[O:20])[CH2:15][CH2:14]3)=[N:12][C:6]2=[CH:5][C:4]=1[O:27][CH3:28].O.O.Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]2[C:9]([NH2:26])=[N:10][C:11]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([CH:21]4[O:25][CH2:24][CH2:23][CH2:22]4)=[O:20])[CH2:15][CH2:14]3)=[N:12][C:6]2=[CH:5][C:4]=1[O:27][CH3:28]

참가 물질

3

반응물 1

HCID 63016Terazosin Hydrochloride

생성물 1

HCID 5401Terazosin

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Terazosin monohydrochloride dihydrate (620 mg, 1.35 mmol) was dissolved in 100 mL of hot absolute ethanol in a 250 mL Erlenmeyer flask fitted with a ground glass joint. The solution was slowly cooled to room temperature and allowed to stand overnight. The resulting white crystalline precipitate was collected by vacuum filtration to yield 100 mg (0.24 mmol, 17.4%) of the anhydrous crystalline polymorph of terazosin of this invention. The material was found by its powder x-ray diffraction pattern to be free of both the prior art anhydrous crystalline modification and the dihydrate form.

후처리

  1. customfitted with a ground glass joint
  2. filtrationThe resulting white crystalline precipitate was collected by vacuum filtration

출처 및 근거

ORD 기록
ord-d59d9fb764014b84b9b64fb74483d498
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05362730

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