Benzoate → Hexan-2-yl 4-hydroxybenzoate

반응식

[C:1]([O-:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:10](N)[C:11]1C=[CH:15][CH:14]=[CH:13][CH:12]=1.ClCCl.C([OH:23])C>>[OH:23][C:5]1[CH:6]=[CH:7][C:2]([C:1]([O:9][CH:14]([CH3:15])[CH2:13][CH2:12][CH2:11][CH3:10])=[O:8])=[CH:3][CH:4]=1

참가 물질

반응물 4

HCID 242Benzoate

HCID 702Ethanol

HCID 6344Dichloromethane

HCID 7504Benzylamine

생성물 1

HCID 19365253Hexan-2-yl 4-hydroxybenzoate수율 100%

실험 절차

Said benzoate (4.7 mmols) was dissolved in 20 ml of ethanol, and 9.7 mmols of benzylamine were added. The mixture was stirred overnight. To the reaction mixture was added 50 ml of dichloromethane. The organic layer was washed with a hydrochloric acid aqueous solution and water in this sequence. Subsequently, the organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated. The obtained crude product was purified by silica gel column chromatography to afford 1-methylpentyl p-hydroxybenzoate in a yield of 100%.