Methyl iodide → 1-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one

HRID 2380054노트

반응식

HRID 2380054 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH2:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1.I[CH3:19]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH:10]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH3:19]

참가 물질

3

반응물 2

HCID 6328Methyl iodideHCID 189565241-(2,4-Difluorophenyl)-2-(3-pyridinyl)-ethanone

생성물 1

HCID 189565411-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one수율 73.6%

실험 절차

Methylation of the product of part (i) (5.0 g) with iodomethane (7.60 g) according to the method of Example 11(ii) gave the title compound as an oil (3.90 g) which was used directly in the next stage.

출처 및 근거

ORD 기록
ord-5b211545779f4b3996fbdab503582604
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05364938

반응 노트

불러오는 중…