Sodium Hydroxide → o-Nitrophenyl cyclopropyl ketone

HRID 2380077노트

반응식

HRID 2380077 반응식
Br[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N+:13]([O-:15])=[O:14])=[O:6].[OH-].[Na+]>O.C(OCC)C>[CH:4]1([C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N+:13]([O-:15])=[O:14])=[O:6])[CH2:2][CH2:3]1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 537739744-Bromo-2'-nitrobutyrophenone

생성물 1

HCID 10487947o-Nitrophenyl cyclopropyl ketone

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

A stirred mixture of 4-bromo-2'-nitrobutyrophenone (3.44 g, 0.013 mole) and NaOH (0.76 g, 0.019 mole) in water is heated at reflux temperature until reaction is complete by TLC, cooled to room temperature and extracted with diethyl ether. The ether extracts are combined, dried over Na2SO4 and concentrated in vacuo to give a dark brown liquid residue. The residue is taken up in diethyl ether, filtered through silica gel and concentrated in vacuo to give the title product as a yellow oil, identified by 1HNMR.

후처리

  1. temperatureis heated
  2. temperatureat reflux temperature
  3. customuntil reaction
  4. extractionextracted with diethyl ether
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated in vacuo
  7. customto give a dark brown liquid residue
  8. filtrationfiltered through silica gel
  9. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0809fa1c0dc04d5da83ccd3896d794dd
출처 데이터셋
uspto-grants-1994_11
특허 번호
US05364968

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