Hydrochloric Acid → HCID 15729196, 화합물
반응식
C([NH:4][C:5]1[S:6][C:7]([S:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[CH:8][N:9]=1)(=O)C.O1CCCC1.Cl>C(O)C>[NH2:4][C:5]1[S:6][C:7]([S:10][C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)=[CH:8][N:9]=1참가 물질
5
실험 절차
A mixture of 2-acetylamino-5-(3-pyridylthio)thiazole (8.5 g) in a mixture of ethanol (160 ml), tetrahydrofuran (50 ml) and aqueous 6N hydrochloric acid (100 ml) was refluxed for 4 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was dissolved in water. The solution was adjusted to pH 8.5 using aqueous sodium bicarbonate and the precipitates were collected by filtration, washed with water and dried in vacuo to give 2-amino-5-(3-pyridylthio)thiazole (5.6 g yield: 78.9%).
후처리
- temperaturewas refluxed for 4 hours
- concentrationThe reaction mixture was concentrated under reduced pressure
- dissolutionthe residue was dissolved in water
- filtrationthe precipitates were collected by filtration
- washwashed with water
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-99348315f00e407cb2b10ac6e0295942
- 출처 데이터셋
- uspto-grants-1994_11
- 특허 번호
- US05369107
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