Methyl iodide → 4-Quinazolinamine, N-(3-fluoro-4-methoxyphenyl)-N,2-dimethyl-

HRID 2380998노트

반응식

HRID 2380998 반응식
[F:1][C:2]1[CH:3]=[C:4]([NH:10][C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=[C:13]([CH3:21])[N:12]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH3:22]I>>[F:1][C:2]1[CH:3]=[C:4]([N:10]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=[C:13]([CH3:21])[N:12]=2)[CH3:22])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

참가 물질

3

반응물 2

HCID 6328Methyl iodideHCID 42625836N-(3-Fluoro-4-methoxyphenyl)-2-methylquinazolin-4-amine

생성물 1

HCID 114606964-Quinazolinamine, N-(3-fluoro-4-methoxyphenyl)-N,2-dimethyl-

실험 절차

The title compound was prepared from (3-fluoro-4-methoxy-phenyl)-(2-methyl-quinazolin-4-yl)-amine (250 mg, 0.88 mmol) and methyl iodide (0.39 ml, 6.18 mmol) by a procedure similar to example 7. 1H NMR (CDCl3): 7.76 (d, J=8.4 Hz, 1H), 7.59-7.53 (m, 1H), 7.09-6.82 (m, 5H), 3.91 (s, 3H), 3.58 (s, 3H), 2.73 (s, 3H).

출처 및 근거

ORD 기록
ord-4aca2f2784e546eeb8cb2e45b86ae761
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08258145B2

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