2,6-Dimethylaniline → N-(2,6-Dimethylphenyl)formamide

HRID 2381052

반응식

HRID 2381052 반응식
[C:1]([O-:4])(=O)C.[Na+].[CH3:6][C:7]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[C:8]=1[NH2:9]>C(O)=O>[CH3:6][C:7]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[C:8]=1[NH:9][CH:1]=[O:4]

참가 물질

4

반응물 2

HCID 68962,6-DimethylanilineHCID 517045Sodium Acetate

생성물 1

HCID 345859N-(2,6-Dimethylphenyl)formamide수율 79%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

4.1 10.0 g of sodium acetate are dissolved in 120 ml of formic acid. 50.0 g of 2,6-dimethylaniline 11 are then introduced, and the mixture is stirred under reflux for 24 h. The mixture is subsequently subjected to conventional work-up, giving 48.9 g (79%) of N-(2,6-dimethylphenyl)formamide 12; MS-EI (M+)=149.

후처리

  1. temperatureunder reflux for 24 h

출처 및 근거

ORD 기록
ord-ecafce52565e444bbd417d8c3ac09ba6
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08258151B2

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