Sodium Hydroxide → 1-(Morpholin-4-ylsulfonyl)piperidine-4-carboxylic acid

HRID 2381180노트

반응식

HRID 2381180 반응식
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([S:12]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)(=[O:14])=[O:13])[CH2:8][CH2:7]1)=[O:5])C.[OH-].[Na+]>CO>[N:15]1([S:12]([N:9]2[CH2:10][CH2:11][CH:6]([C:4]([OH:5])=[O:3])[CH2:7][CH2:8]2)(=[O:14])=[O:13])[CH2:16][CH2:17][O:18][CH2:19][CH2:20]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 3422241HCID 3422241, 화합물

생성물 1

HCID 32397731-(Morpholin-4-ylsulfonyl)piperidine-4-carboxylic acid수율 79.4%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
85 °C

실험 절차

1-(Morpholine-4-sulfonyl)-piperidine-4-carboxylic acid ethyl ester (1.9 g) dissolved in methanol (80 ml) was treated at RT with 2M NaOH (15.5 ml) and the mixture was then heated at 85° C. for 12 h. The solvent was then evaporated off, the residue partitioned between methylene chloride and 1N HCL, the layers were separated and the organic layer washed with 2M aqueous KHCO3, dried over Na2SO4 and concentrated in vacuo to give 1-(morpholine-4-sulfonyl)-piperidine-4-carboxylic acid (1.37 g) as a white solid. MS (ESI): 277.08 ([M-H]−).

후처리

  1. customThe solvent was then evaporated off
  2. customthe residue partitioned between methylene chloride and 1N HCL
  3. customthe layers were separated
  4. washthe organic layer washed with 2M aqueous KHCO3
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-3ec7bd2d5457490db0cd26bd40e48906
출처 데이터셋
uspto-grants-2012_09
특허 번호
US08258158B2

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